The expert of our country finds two pieces of leprosy and exchanges the sense gene again

The expert of our country finds two pieces of leprosy and exchanges the sense gene again
The expert of our country finds two pieces of leprosy and exchanges the sense gene again
It is reported ' Reporter Zhang ZhongTian) Units such as Shandong dermatosis research institute of prevention and treatment of venereal diseases,etc., pass the study on 10531 leprosy cases and persons who contrast healthily, finding 2 pieces of new leprosy exchanges the sense gene, has and proved one among them is involved in infectious disease for the first time in the world. At the same time, through exchanging the sense gene and carrying on comprehensive analysis to 9 pieces of leprosy already found so far, find that 2 genes have reciprocation, the ill risk that can increase leprosy at double exists at the same time. Internationally famous academic periodical " natural science of heredity " issue of our country above-mentioned research results of scientist online October 24. This to continue of our country scientist to utilize the whole the intersection of gene and related analytical method take the lead in, find 7 leprosy exchange after the sense gene for the first time in the world 2009, another original achievement made in this field. 2009, the research group which a good fortune benevolence researcher of research institute of prevention and treatment of venereal diseases of Shandong dermatosis led, unite the one of institute of internal medicine of medical university of Anhui and learn military affairs in professor's group and Singapore state-run genetic Professor Liu Jianjun of research institute group, adopt the related analytical method of the whole genome, has taken the lead in finding 7 pieces of leprosy and exchanging the sense gene in the world. According to the introduction of researcher Zhang FuRen, this research is united once again by the above-mentioned 3 groups, regard key laboratory of Shandong dermatosis' venereology as and study the platform, contrast samples through expanding, click, prove to 24 suspicious location, find 2 pieces of new leprosy exchange the sense gene further: IL-23R, RAB32, and verify IL-23R is involved in infectious disease, this gene influences the " biting by oneself " of cells for the first time Function; RAB32 is correlated with phagocyting to the recognition of the pathogenic microbe. Group of this research has analyzed 9 pieces of leprosy successively found and exchanged the sense gene synthetically, revealed finally NOD2 and RIPK2 had reciprocation, activated NF - �� B thorough fare together, this thorough fare influenced the host to the immune defence infected, but increase the ill risk of leprosy greatly.


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